Formación Académica

Interés Científico

Líneas de Investigación:

1. Raibel Suarez, Carolina Villarreal, Yessica Nahuelpan, Claudia Jara, Carlos Oyarzún, Sebastian Alarcon, Montserrat M. Díaz-Encarnacion, Elena Guill´en-Gomez, Claudia Quezada, Rody San Martín (2023). Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis in diabetic kidney disease progression. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. Vol 1870, Issue 1, 166890. (ISI 4.1).

2.Volume1José Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, Giovanna Navarro-Martínez, Ángelo Torres, Rody San Martín, Juan Carlos Roa, and Claudia Quezada-Monrás (2023). Glioblastoma Microenvironment and Invasiveness: New Insights and Therapeutic Targets. Int J Mol Sci.; 24(8): 7047. (ISI 5.6).

3. Ignacio Niechi, José I. Erices, Diego Carrillo-Beltrán, Atenea Uribe-Ojeda, Ángelo Torres, José
Dellis Rocha, Daniel Uribe, María A. Toro, Karla Villalobos-Nova, Belén Gaete-Ramírez, Gabriel
Mingo, Gareth I. Owen, Manuel Varas-Godoy, Lilian Jara, Francisco Aguayo, Verónica A. Burzio,
Claudia Quezada-Monrás, and Julio C. Tapia. (2023) Cancer Stem Cell and Aggressiveness Traits
Are Promoted by Stable Endothelin-Converting Enzyme-1c in Glioblastoma Cells. Cells.12(3): 506.
(ISI 6.0).

4. Andrés Tittarelli, Omar Barría, Evy Sanders, Anna Bergqvist, Daniel Uribe Brange, Mabel Vidal,
María Alejandra Gleisner, Jorge Ramón Vergara, Ignacio Niechi, Iván Flores, Cristián Pereda,
Cristian Carrasco, Claudia Quezada-Monrás and Flavio Salazar-Onfray. (2023) Co-Expression of
Immunohistochemical Markers MRP2, CXCR4, and PD-L1 in Gallbladder Tumors Is Associated
with Prolonged Patient Survival. Cancers, 15, 3440. (ISI 5.2).

5. Pérez-Baños A, Gleisner MA, Flores I, Pereda C , Navarrete M, Araya JP, Navarro G, Quezada-
Monrás C , Tittarelli A, Salazar-Onfray F. (2023) Whole tumour cell-based vaccines: tuning the instruments to orchestrate an optimal antitumour immune response. (2023). British Journal of Cancer, 24 Jun 2023. (ISI 9.082).

6. Ángelo Torres-Arévalo, Yéssica Nahuelpán, Katherin Muñoz, Claudia Jara, Claudio Cappelli,
Agnieszka Taracha-Wis ́niewska, Claudia Quezada-Monrás and Rody San Martín. (2023) A2BAR
Antagonism Decreases the Glomerular Expression and Secretion of Chemoattractants for Monocytes and the Pro-Fibrotic M2 Macrophages Polarization during Diabetic Nephropathy. Int. J. Mol. Sci., 24, 10829. Int. J. Mol. Sci., 24, 10829. (ISI 5.6).

7. Rocha, JD., Uribe B., D., Delgado, J., Niechi, I., Alarcón, S., Erices, JI., Melo, R., Fernández-
Gajardo, R., Salazar-Onfray, F., San Martin, R., Quezada CA. (2022) A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New Insights into MRP3 Transporter Function. International Journal of Molecular Sciences. 23(16). (ISI 5.6).

8. Erices, JI., Niechi, I., Uribe-Ojeda, M., García-Romero, N., Carrión-Navarro, J., Monago-Sánchez, A., Ayuso-Sacido, A., San Martin, R., Quezada CA. (2022) The low affinity A2B adenosine receptor enhances migratory and invasive capacity in vitro and angiogenesis in vivo of glioblastoma stem-like cells. Frontiers in Oncology. 12(969993). (ISI 5.738).

9. Daniel Uribe, Ignacio Niech, Gorjana Rackov, José I. Erices, Rody San Martín and Claudia
Quezada. (2022) Adapt to Persist: Glioblastoma Microenvironment and Epigenetic Regulation on
Cell Plasticity. Biology, 11(2), 313. (ISI 4.2)

10. Carrasco C, Tittarelli A, Paillaleve N, Pozo MD, Rojas-Sepúlveda D, Barría O, Fluxá P, Hott M, Martin C, Quezada C, Salazar-Onfray F. (2021) The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients. Diagnostics (Basel) 11(2):153. doi: 10.3390/diagnostics11020153 (ISI 3.6).

11. Sebastián Alarcón, María de los Ángeles Toro, Carolina Villarreal, Rómulo Melo, Rodrigo
Fernández, Ángel Ayuso Sacido, Daniel Uribe, Rody San Martín, Claudia Quezada (2020). Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells. Cells. 9(8):
1914. (ISI 6.0).

12. Gorjana Rackov, Giorgia Iegani, Daniel Uribe, Claudia Quezada, José A. Garcia-Sanz, Cristábal belda- Iniesta, Carmen Escobedo-Lucea, Augusto Silva, Víctor González-Rumayor, Ángel Ayuso-Sacido (2020). Nilo1 monoclonal antibody inhibits the growth of patient-derived glioblastoma stem cells. Differential sensitivity to Nilo 1 monoclonal antibody stratifies patient-derived glioblastoma
cells. Front. Oncol. 2020. doi.org/10.3389/fonc.2020.01665. (ISI 5.738).

13. Torres Á, Muñoz K, Nahuelpán Y, R Sáez AP, Mendoza P, Jara C, Cappelli C, Suarez R, Oyarzún C, Quezada C, San Martín R. (2020) Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B
Adenosine Receptor. Cells 9(4):1051. doi: 10.3390/cells9041051. (ISI 6.0).

14. Cappelli C, Tellez A, Jara C, Alarcón S, Torres A, Mendoza P, Podestá L, Flores C, Quezada C,
Oyarzún C, San Martín R. (2020) The TGF-β profibrotic cascade targets ecto-5′-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease.
Biochim Biophys Acta Mol Basis Dis. 1866(7):165796. doi: 10.1016/j.bbadis.2020.165796. (ISI 6.32)

15. Touma J, Navarro M, Sepúlveda B, Pavon A, Corsini G, Fernández K, Quezada C, Torres A,
Larrazabal-Fuentes MJ, Paredes A, Neira I, Ferrando M, Bruna F, Venegas A, Bravo J. (2020) The
Chemical Compositions of Essential Oils Derived from Cryptocarya alba and Laurelia sempervirens
Possess Antioxidant, Antibacterial and Antitumoral Activity Potential. Molecules 25(23):5600. doi:
10.3390/molecules25235600. (ISI 4.6).

16. Torres A, Erices J.I, Ehrenfeld I.P., Sanchez F., Virolle T., Uribe U., Rocha D., Niechi I., Ramirez M., San Martín R., and Quezada C. (2019) Extracellular Adenosine controls the cell migration/invasion of Glioblastoma Stem-like Cells through the activation of A3 Adenosine
Receptor under Hypoxia. Cancer Letters 446:112-12. (ISI 9.7).

17. Alarcón S, Niechi I, Toledo F, Sobrevia L, Quezada C. (2019) Glioma progression in diabesity. Mol Aspects Med. 66:62-70. (ISI 10.6).

18. Guequén A, Zamorano P, Aguilar G, Córdova F, Boric M, Durán W, Salazar-Onfray F., Quezada C, Ehrenfeld P, Sarmiento J, Sánchez F. (2019) Interleukin 8 from glioblastoma-cell line U87 induces microvascular hyperpermeability through S-nitrosylation of p120 and VE-cadherin. Front Physiol. 10:988 (ISI 4.0)

19. Garrido W, Jara C, Torres A, Suarez R, Cappelli C, Oyarzún C, Quezada C, San Martín R. (2019) Blockade of the Adenosine A3 Receptor Attenuates Caspase 1 Activation in Renal Tubule Epithelial Cells and Decreases Interleukins IL-1β and IL-18 in Diabetic Rats. Int J Mol Sci. 20(18). pii: E4531.(ISI 5.6).

20. Niechi I, Uribe-Ojeda A, Erices JI, Torres Á, Uribe D, Rocha JD, Silva P, Richter HG, San Martín R, Quezada C. Adenosine Depletion as A New Strategy to Decrease Glioblastoma Stem-Like Cells Aggressiveness. Cells. 2019; 8(11). pii: E1353. (ISI: 6.0).

21. Quezada C, Torres Á, Niechi I, Uribe D, Contreras-Duarte S, Toledo F, San Martín R, Gutiérrez J, Sobrevia L. (2018) Role of extracellular vesicles in glioma progression. Mol Aspects Med. 60:38-51.doi: 10.1016/j.mam.2017.12.003. (ISI 10.6).

22. Rocha, R., Torres, A., Ojeda, K., Uribe, D., Rocha, D., Erices, J.I., Niechi, I., San Martín, R., and Quezada, C. (2018) The Adenosine A3 Receptor regulates differentiation of Glioblastoma Stem-like Cells to Endothelial Cells under Hypoxia. International Journal Molecular Sciences 19(4). (ISI: 5.6).

23. José Ignacio Erices, Ángelo Torres, Ignacio Niechi, Isabel Bernales and Claudia Quezada. (2018) Current Natural therapies in the treatment against Glioblastoma. Phytotherapy Research
32(11):2191- 2201 (ISI 7.2).

24. Ángelo Torres, Valentina Arriagada, José Ignacio Erices, Maria de los Angeles Toro, Ignacio Niechi, Carlos Oyarzun and Claudia Quezada (2018) FK506 attenuates the MRP1-mediated chemoresistant phenotype in Glioblastoma stem like cells. International Journal Molecular Sciences 11;19(9). (ISI:5.6).

Responsable:

Colaboradora:

PROYECTOS VIGENTES 

2020-2024        Investigadora Responsable Proyecto FONDECYT REGULAR 2020 “Several mechanisms of therapeutic resistance are regulated through adenosine signaling in glioblastoma stem-like cells” (N°1200885). 

2022-2027      Investigadora Principal Instituto Milenio de Inmunología e Inmunoterapia (IMII). ICN2021_045. 

2021-2023        Directora Proyecto FIC21-19 “Terapia personalizada en Cáncer de Vesícula Biliar”. Proyecto Fondos regionales de investigación para la competitividad.  Colaborativo con el Hospital Base Valdivia e Instituto Milenio de Inmunología e Inmunoterapia. 

2022-2025        Profesora Patrocinante Proyecto Postdoctorado CONICYT. “Glycosylated delphinidins as a sensitizing compound to temozolomide treatment in glioblastoma cells by regulating NF-κB/MGMT and COX- 2/MDR1 signaling” (N°3220237). Dr. Diego Carrillo. 

2021-2025                 Co-investigadora Proyecto FONDECYT REGULAR 2021  “Blockade of podocyte dedifferentiation and fibrosis in diabetic nephropathy through adenosine A2B receptor antagonism” (Nª 1211613).

2019-2022        Investigadora Responsable Proyecto VIII CONCURSO DE EQUIPAMIENTO CIENTÍFICO TECNOLÓGICO MEDIANO – FONDEQUIP. “Actualización de la unidad de aislamiento y caracterización de subpoblaciones celulares implicadas en patologías de humanos y animales”. Equipo citómetro con cell sorter FACS Melody marca BD.

Colaboraciones

Contacto: