Formación Académica

Interés Científico

Líneas de Investigación:

1. Diego Carrillo-Beltrán, Yessica Nahuelpan, Constanza Cuevas, Karen Fabres, Pamela Silva, Jimena Zubieta, Juan P. Muñoz, Noemi García-Romero, Ángel Ayuso-Sacido, Rody San Martin and Claudia Quezada-Monrás. (2025) Glycosylated delphinidins decrease chemoresistance to Temozolomide by regulating NF-kB/MGMT signaling in glio-blastoma. Cells, 14(3), 179.
2. Francisco Pérezz-Domínguez, Claudia Quezada-Monrás, Juan P. Muñoz Diego Carrillo-Beltrán. (2025) Oncolytic Viruses as a Novel Therapeutic Approach for Colo-rectal Cancer: Mechanisms, Current Advances and Future Directions. Cancers 3612901.
3. Liuba Peñate, Diego Carrillo-Beltrán, Carlos Spichiger, Alexei Cuevas-Zhbankova, Ángelo Torres- Arévalo, Pamela Silva, Ángel Ayuso-Sacido, Rody San Martín, Claudia Quezada-Monrás. (2024) The impact of A3AR antagonism on the differential expression of chemoresistance-related genes in glioblastoma stem-like cells. Pharmaceuticals 17(5), 579.
4. Pablo Mendoza-Soto, Claudia Jara, Ángelo Torres-Arévalo, Carlos Oyarzún, Gonzalo A Mardones, Claudia Quezada-Monrás, Rody San Martín. (2024) Pharmacological blockade of the adenosine A2b receptor attenuates proteinuria in diabetic rats, affecting focal adhesion kinase activation and the adhesion dynamics of podocytes. Cells 16;13(10):846.
5. Suárez, R., Villarreal, C., Nahuelpán, Y., Jara, C., Oyarzun, C., Alarcón, S., Díaz-Encarnación, MM., Guillén-Gómez, , Quezada CA., San Martin, R. (2024) Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis indiabetic kidney disease progression. Biochimica et Biophysica Acta-Molecular Basis of Disease. 1870(1)
6. José Ignacio Erices, Carolina Bizama, Ignacio Niechi, Daniel Uribe, Arnaldo Rosales, Karen Fabres, GiovannaNavarro-Martínez, Ángelo Torres, Rody San Martín, Juan Carlos Roa, and Claudia Quezada- Monrás (2023). Glioblastoma Microenvironment and Invasiveness: New Insights and Therapeutic Targets. Int J Mol Sci.; 24(8): 7047.
7. Ignacio Niechi, José Erices, Diego Carrillo-Beltrán, Atenea Uribe-Ojeda, Ángelo Torres, José Dellis Rocha, Daniel Uribe, María A. Toro, Karla Villalobos-Nova, Belén Gaete-Ramírez, Gabriel Mingo, Gareth I. Owen, Manuel Varas-Godoy, Lilian Jara, Francisco Aguayo, Verónica A. Burzio, Claudia Quezada-Monrás, andJulio C. Tapia. (2023) Cancer Stem Cell and Aggressiveness Traits Are Promoted by Stable Endothelin-Converting Enzyme-1c in Glioblastoma Cells. Cells.12(3): 506.
8. Andrés Tittarelli, Omar Barría, Evy Sanders, Anna Bergqvist, Daniel Uribe Brange, Mabel Vidal, MaríaAlejandra Gleisner, Jorge Ramón Vergara, Ignacio Niechi, Iván Flores, Cristián Pereda, Cristian Carrasco, Claudia Quezada-Monrás and Flavio Salazar-Onfray. (2023) Co-Expression of Immunohistochemical Markers MRP2, CXCR4, and PD-L1 in Gallbladder Tumors Is Associated with Prolonged Patient Survival. Cancers, 15, 3440.
9. Pérez-Baños A, Gleisner MA, Flores I, Pereda C , Navarrete M, Araya JP, Navarro G, Quezada- Monrás C , Tittarelli A, Salazar-Onfray F. (2023) Whole tumour cell-based vaccines: tuning the instruments to orchestratean optimal antitumour immune (2023). British Journal of Cancer, 24 Jun 2023.
10. Ángelo Torres-Arévalo, Yéssica Nahuelpán, Katherin Muñoz, Claudia Jara, Claudio Cappelli, Agnieszka Taracha-Wisńiewska, Claudia Quezada-Monrás and Rody San Martín. (2023) A2BAR Antagonism Decreasesthe Glomerular Expression and Secretion of Chemoattractants for Monocytes and the Pro-Fibrotic M2Macrophages Polarization during Diabetic Int. J. Mol. Sci., 24, 10829. Int. J. Mol. Sci., 24, 10829.
11. Rocha, , Uribe B., D., Delgado, J., Niechi, I., Alarcón, S., Erices, JI., Melo, R., Fernández- Gajardo, R., Salazar-Onfray, F., San Martin, R., Quezada CA. (2022) A2B Adenosine Receptor Enhances Chemoresistance of Glioblastoma Stem-Like Cells under Hypoxia: New Insights into MRP3 Transporter Function. International Journal of Molecular Sciences. 23(16).
12. Erices, JI., Niechi, I., Uribe-Ojeda, M., García-Romero, N., Carrión-Navarro, J., Monago-Sánchez, A., Ayuso-Sacido, A., San Martin, R., Quezada CA. (2022) The low affinity A2B adenosine receptor enhances migratory and invasive capacity in vitro and angiogenesis in vivo of glioblastoma stem-like cells. Frontiers in Oncology. 12(969993).
13. Daniel Uribe, Ignacio Niech, Gorjana Rackov, José I. Erices, Rody San Martín and Claudia Quezada. (2022) Adapt to Persist: Glioblastoma Microenvironment and Epigenetic Regulation on Cell Plasticity. Biology, 11(2), 313.
14. Carrasco C, Tittarelli A, Paillaleve N, Pozo MD, Rojas-Sepúlveda D, Barría O, Fluxá P, Hott M, Martin C, Quezada C, Salazar-Onfray F. (2021) The Evaluation of 17 Gastrointestinal Tumor Markers Reveals Prognosis Value for MUC6, CK17, and CD10 in Gallbladder-Cancer Patients. Diagnostics (Basel) 11(2):153.
15. Sebastián Alarcón, María de los Ángeles Toro, Carolina Villarreal, Rómulo Melo, Rodrigo Fernández, Ángel Ayuso Sacido, Daniel Uribe, Rody San Martín, Claudia Quezada (2020). Decreased Equilibrative Nucleoside Transporter 1 (ENT1) Activity Contributes to the High Extracellular Adenosine Levels in Mesenchymal Glioblastoma Stem-Like Cells. 9(8): 1914.
16. Gorjana Rackov, Giorgia Iegani, Daniel Uribe, Claudia Quezada, José A. García-Sanz, Cristábal belda- Iniesta, Carmen Escobedo-Lucea, Augusto Silva, Víctor González-Rumayor, Ángel Ayuso- Sacido (2020). Nilo1 monoclonal antibody inhibits the growth of patient-derived glioblastoma stem cells. Differential sensitivity to Nilo 1 monoclonal antibody stratifies patient-derived glioblastoma cells. Oncol. 2020. doi.org/10.3389/fonc.2020.01665.
17. Torres Á, Muñoz K, Nahuelpán Y, R Sáez AP, Mendoza P, Jara C, Cappelli C, Suarez R, Oyarzún C, Quezada C, San Martín R. (2020) Intraglomerular Monocyte/Macrophage Infiltration and Macrophage- Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor. Cells 9(4):1051.
18. Cappelli C, Tellez A, Jara C, Alarcón S, Torres A, Mendoza P, Podestá L, Flores C, Quezada C, Oyarzún C, San Martín R. (2020) The TGF-β profibrotic cascade targets ecto-5′-nucleotidase gene in proximal tubule epithelial cells and is a traceable marker of progressive diabetic kidney disease. Biochim Biophys Acta Mol Basis Dis. 1866(7):165796. doi: 10.1016/j.bbadis.2020.165796.
19. Touma J, Navarro M, Sepúlveda B, Pavon A, Corsini G, Fernández K, Quezada C, Torres A, Larrazabal-Fuentes MJ, Paredes A, Neira I, Ferrando M, Bruna F, Venegas A, Bravo J. (2020) The Chemical Compositions of Essential Oils Derived from Cryptocarya alba and Laurelia sempervirens Possess Antioxidant, Antibacterial and Antitumoral Activity Potential. Molecules 25(23):5600. doi: 10.3390/molecules25235600.

Responsable:

Colaboradora:

PROYECTOS VIGENTES 

2024-2028 Investigadora Responsable Proyecto FONDECYT REGULAR 2024 “AdenosineA2B receptor pharmacological blockade affects mesenchymal phenotype of glioblastoma stem- like cells: Evaluation of a novel strategy targeting chemo and radiotherapy resistance” (N° 1241275).

2022-2027 Investigadora Principal Instituto Milenio de Inmunología e Inmunoterapia (IMII). CN2021_045.

2021-2025 Directora Proyecto FIC21-19 “Terapia personalizada en Cáncer de Vesícula Biliar” Proyecto Fondos regionales de investigación para la competitividad. Colaborativo con el Hospital Base Valdivia e Instituto Milenio de Inmunología e Inmunoterapia.

2024-2027 Investigadora Patrocinante Proyecto Postdoctorado ANID. “Study of Chemosensitization of Mesenchymal Glioblastoma Stem Cells by Adenosine A2B Receptor Antagonism” (N°3240689). Dr. Alexei Cuevas

2022-2025 Investigadora Patrocinante Proyecto Postdoctorado ANID. “Glycosylated delphinidins as a sensitizing compound to temozolomide treatment in glioblastoma cells by regulating NF- κB/MGMT and COX- 2/MDR1 signaling” (N°3220237). Dr. Diego Carrillo.

2021-2025 Co-investigadora Proyecto FONDECYT REGULAR 2021 “Blockade of podocyte dedifferentiation and fibrosis in diabetic nephropathy through adenosine A2B receptor antagonism” (Nª 1211613).

Colaboraciones

Contacto:

Reconocimiento Medalla 02 de Octubre de la Región de los Ríos en la categoría “Ciencia e Innovación”. Gobierno Regional-Región de Los Ríos. Chile. (2022)